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That extended duration is what makes weekly dosing possible, but it also means the body is exposed to sustained amylin receptor activation far beyond what natural physiology produces

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Even with peptide support, meaningful structural improvement in shoulder tendons takes weeks to months

Bae et al

Up to 72 hours can lapse between the precipitating pressure event and the onset of purple or maroon skin, so a longer time window is needed to exclude cases when the precipitating event occurred before the patient's admission