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Sci Rep 6:31899 Chin Y-T, Wang L-M, Hsieh M-T, Shih Y-J, Nana AW, Changou CA, Yang Y-CS, Chiu H-C, Fu E et al (2017) Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells

But at least in that paper IV NAC did boost Brain levels include glutathione

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This results in a higher risk of cardiovascular disease and hypertension (high blood pressure)