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In some embodiments, the otic formulation or composition comprises about 0.01% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Stability Active in acidic environments Unlike conventional peptides, BPC-157 remains stable for more than 24 hours in gastric juice

[11] Use is not recommended in those who are allergic to cobalt or have Leber's disease

Classic BPC-157 has the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val and a molar mass of approximately 1419 Da

In addition, the kidneys may excrete more holoTC (usable B12) in urine if reabsorption is impaired, reducing availability further