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those are separate questions the chamber studies were never designed to answer

If you have too little GSH, you cant fight off your cells mitochondria

Wenthold RJ, Petralia RS, Blahos II J, Niedzielski AS (1996)

Obesity-associated oxidative stress: strategies finalized to improve redox state

Moreover, multi-targeted nanoparticle systems combining ferroptosis inhibition with anti-inflammatory or antioxidant therapy show promise in enhancing drug delivery and therapeutic efficacy ( 3.2.2 Intra-articular therapies Intra-articular (IA) therapies represent a key component of localized pharmacologic management in OA, particularly for patients who exhibit inadequate response to oral medications or are contraindicated for systemic therapy