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demonstrated that secondary metabolites produced during P

Detoxification of harmful lipid peroxides (Lipid-OOH) to their corresponding hydroxides (lipid-OH) by glutathione peroxidase 4 (GPX4) and glutathione-S-transferases (GST)

This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences

Additionally, PDOs have been widely used for predicting drug sensitivity in CRC and can be combined with mitochondrial function dyes (e.g., JC-1, TMRM) to perform metabolic dependency-based individual screening [178]

X.et al (2019)