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doi:10.4236/ijcm.2012.33034 Richardson J

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Velasco, P

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These findings suggest that the accumulation of IS in serum during renal excretory deterioration increases the NOX4-mediated oxidative stress burden, and has a deleterious effect on endothelium-dependent vasodilatation and transdifferentiation of VSMCs to the osteoblastic phenotype, which is involved in the development of vascular calcification in CKD patients

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33 T2DM has also been linked to a faster progression of NASH, cirrhosis, or HCC

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