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Multi-target-directed ligands (MTDL) as challenging research tools in drug discovery: From design to pharmacological evaluation
The addition of a negative charge to the normally neutral hydroxyl moiety of tyrosine can profoundly alter protein shape and function through electrostatic interactions, and nitration is often quite spatially specific due to the high reactivity of superoxide and peroxynitrite
Contributing factors may include B12 or folate deficiency (since methionine generation requires these nutrients), or excessive SAMe utilization in polyamine synthesis as part of a maladaptive chronic inflammatory response to tau pathology (10, 11)
Th2 cytokines include IL-4, IL-5, IL-9, and IL-13, all of which are linked to the immunoglobulin response
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