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The authors proposed multiple potential mechanisms including interactions with opioid, GABAergic, and monoaminergic systems, establishing the conceptual framework for subsequent mechanistic research into DSIP's neurophysiological actions

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Given the important central role of this cofactor and its relevance to mitochondrial function, this review will provide an extensive summary of the NAD + homeostasis and modulation approaches, of the various mechanisms of NAD + -mediated mitochondrial regulation, and how the functional link between NAD + and mitochondria has been investigated in the context of preclinical and clinical settings of aging and disease