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4 In this context, an understanding of the antioxidant systems is critical, and one such important system is thioredoxin

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This means that the clinical effectiveness of GSHand that of its precursors like NACis dependent not only on its capability to act as an antioxidant, but also the degree to which their pharmacodynamic properties are in line with the dysfunction in cellular signaling, redox imbalance, and immune response generated by specific disease states (Vzquez-Meza et al., 2023)