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If a patient still has opioids present which are full agonists (use of short acting opioid less than 12 hours ago or long-acting opioid use, such as methadone, less than 48 hours ago), administration of buprenorphine, a partial mu agonist, will displace the full agonist and precipitate withdrawal symptoms

[71] The following table summarizes the applicant's assertions regarding the substantial clinical improvement criterion

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