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Pharmacological intervention with a first-generation senolytic navitoclax (ABT263), a Bcl-2 inhibitor, modulated tau aggregation (Bussian et al., 2018) but had bone marrow toxicity (thrombocytopenia, low blood platelet count)

J Hazard Mater 217218:382390

The antioxidant is present in a number of common foods, including eggs, nuts, legumes, fish and chicken

Hyperglycemia increases notch activity in vitro and vivo, and consistent activation of notch results in impaired GSIS and blocks maturation of cells, which may be a result of degradation of MAFA due to the blockage of its binding to kat2b