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Initial studies were performed on mouse embryos with targeted disruption of either Hgf or Met locus (Ebens et al., 1996

Skipping or shortening washout periods reduces the efficacy of subsequent cycles by up to 50% because of incomplete receptor recovery

This preclinical data provides an excellent base for human safety and efficacy trials [25]

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We therefore suggest for future studies on monothiol mechanism (i) to take the bulkiness of the putative Grx(SSR) intermediate, an S N 2 reaction geometry, and a possible accumulation of Grx(SSR) as an artifact into account (Fig