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Separate high-dose oral b12 (1000 to 2000 mcg daily) or regular b12 injections (1000 mcg weekly or monthly) offer more reliable repletion

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Inadequate use of vitamin B 12 , which may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia Pernicious anemia is the most common cause of vitamin B 12 deficiency

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The absorption rate through sublingual tissue may differ significantly from subcutaneous injection, which could affect both the timing and magnitude of therapeutic effects