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Ascenzi F, Barberi L, Dobrowolny G, Villa Nova Bacurau A, Nicoletti C, Rizzuto E, Rosenthal N, Scicchitano BM, Musaro A

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Researchers and clinicians are increasingly dependent on results obtained by steroid metabolome analysis, but are often unfamiliar with the metabolic pathways resulting in the observed steroid profile and the distinct metabolic pathways explaining the differences between serum and urine steroid metabolomes

The slow accumulation of the FAD-thiolate charge transfer indicates that the si face of the isoalloxazine is largely secluded from solvent such that equilibrium deprotonation of C159 is achieved over relatively long timeframes

All behavioral procedures were approved by the Animal Care Committee at Centre for Addiction and Mental Health