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In addition, low oestrogen status may reduce endogenous conversion of phosphatidycholine to choline (as reviewed by Derbyshire, 2019) suggesting that the menopause is a time when women experience a rapid change to the enzymatic control of endogenous choline production

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This evidence is not historical it is current, growing, and independently verifiable by any researcher before placing a first order

For example, one of the key insights in systems basal ganglia research within the last decades was the finding that the basal ganglia, thalamus, and cerebral cortex are components of anatomical circuits with separate territories in the individual anatomical nodes of the networks for motor, associative, and limbic functions [42, 43]

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