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FDA and similar regulators worldwide have not approved GHK-Cu as a drug or supplement, meaning it cannot be sold for human or medical application

These transcription factors are involved in the synthesis of several antioxidant enzymes (e.g., glutathione reductase, glutathione peroxidases, glutaredoxin, and glutathione- S -transferase), many of which are closely related to the cellular antioxidant, glutathione (Espinosa-Diez et al

ncRNA can directly target ferroptosis-related molecules or downstream target genes and proteins in the form of miRNAmRNA, IncRNAmiRNA, IncRNAmRNA, circRNAmiRNA, and other regulatory networks to affect ferroptosis in tumor cells

S12B, S12C)

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