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As always, please consult your health care practitioner who has knowledge about the mechanism of action of such herbal preparations and their possible interactions with any medications that you might be on

However, the mechanisms by which IGF-1 plays in the inflammatory response have been mostly elusive

Copper toxicity concerns are generally minimal with topical applications due to limited systemic absorption

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I think that if we look at the literature, the scientific literature, it is extremely hard to get hypercalcemia, which would be the major concern with really high levels of vitamin D3 supplementation