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However, when the brain is in a state of high metabolic demand, such as during learning or memory processing, pyruvate is instead reduced to lactate by lactate dehydrogenase A (LDHA) using hydrogen supplied by NADH

Ethics statement The studies involving humans were approved by the University of Helsinki, Faculty of Medicine

Glutathione and Brain Health The brain is vulnerable to oxidative stress due to its oxygen consumption and high metabolic rate

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Studies have confirmed that IGFs play important roles in drug resistance in tumors, including the IGF-1/IGF-2/IGF-1R signaling axis and the IGFBP family members that reduce the susceptibility of cancers such as lung and breast cancers to chemotherapy resistance (130,131)