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A small subset of patients has antibiotic-refractory chronic pouchitis and requires treatment with corticosteroids (eg, budesonide), immunomodulatory medications, biologicals, or surgery (pouch excision or diversion)

The assumption that high-dose synthetic BPC-157 injection has the same effects as the endogenous gastric compound is not yet proven

Quality control issues present practical safety concerns beyond inherent peptide properties

[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

The absence of muscle-building effects means weight changes reflect primarily fat loss rather than mixed body recomposition