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Treatment with the muscarinic cholinergic receptor antagonist scopolamine renders rats acutely amnesic and therefore unable to learn the task

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SSNMR studies by the group of Wickner on recombinant PMEL fibrils (McGlinchey et al., 2009), combined with mass-per-length measurements (McGlinchey et al., 2011b) provided structural evidence of an in-register parallel -sheet arrangement with two Pmel17 domain per fibril layer

That targeted interaction drives its core effects: Cardiolipin stabilization: By binding cardiolipin, SS31 preserves the structural integrity of the mitochondrial inner membrane, maintaining the cristae architecture that the electron transport chain depends on for efficient ATP production