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The analog information is the epigenome the structures within the cell that allow some genes to be read while keeping others silent

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Of particular pathogenic significance, intestinal epithelial TLR4 activation stimulates systemic release of high-mobility group box 1 (HMGB1), a prototypic damage-associated molecular pattern (DAMP) that mediates remote pulmonary parenchymal injury via hematogenous dissemination (Sodhi et al., 2015)