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ATP-binding cassette transporter A4 (ABCA4) facilitates the movement of atRAL from the photoreceptor outer segment disk to the cytoplasm, whereas RDH8 enzymes are responsible for converting atRAL back into all- trans retinol (249)
Yuan JJ, Chang XN, Li M, Yuan QX, Yang XL
8 Conclusion Neurodegenerative disorders continue to pose an immense clinical and societal challenge, largely because effective neuroprotective agents fail to reach the brain at sufficient concentrations to exert meaningful therapeutic effects
The method according to claim 1 or 2, the use according to any one of claims 3-6, or the composition according to claim 7 or 8, wherein the subject is a subject which has low levels of GSH or tGSH