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If treatment is recommended, a clinician evaluation and valid prescription are required

Ongoing trials Trials like NCT07328100 (intravenous coenzyme I for vascular aging, 2026 start) and NCT05243290 (oral NR in Gulf War Illness) continue to expand the human evidence base

Ursodeoxycholic acid (UDCA) has been found ineffective for pruritus relief in primary sclerosing cholangitis and primary biliary cholangitis but is recommended for treating pruritus in intrahepatic cholestasis of pregnancy only, at doses of 1015 mg/kg/day, divided into 23 doses

They would also like to thank Kansas State University (Manhattan, USA) and the National Institute of the Republic of Serbia (Novi Sad, Serbia) for their generous support and guidance throughout the research period