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Pregnancy and breastfeeding represent absolute contraindications requiring immediate discontinuation regardless of dose

[PubMed] [Google Scholar] 34.Thimmulappa RK, Lee H, Rangasamy T, et al

352 Additionally, research has shown that elevated uric acid levels inhibit insulin-induced glucose uptake in cardiomyocytes

They are naturally occurring in the body and typically have fewer side effects compared to pharmaceuticals, as they are designed to target specific biological functions