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Patients with acute liver failure exhibit impaired hepatocyte proliferation, which is accompanied by an intense DR

762 Notably, acute injuries generally trigger rapid repair mechanisms to restore liver function and often retain better regenerative potential as long as the liver structure remains intact

[(accessed on 17 March 2025)]

The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment

Journal of strength and conditioning research, 36(8), 21982203