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Neuroscience and Biobehavioral Reviews via PubMed (PMID 29733881), 2018 The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases (review note the authors were affiliated with M3 Biotechnology, a company commercializing dihexa)

Each one is preventable if you know what to watch for

Toxicity of intermediates was higher than that of the parent molecule (assessment with the use of Microtox bioassay)

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While direct evidence linking peptide use to PJI or implant failure is lacking, the absence of high-quality safety data should not be interpreted as reassurance