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Most patients report increased energy, elevated mood, and improved focus within 4-10 days of starting B12 therapy at La Vie Clinic

Laustsen G, Wimett L

That said, signs or symptoms that you may be low in vitamin B12 include: fatigue pale skin headaches symptoms of depression stomach issues difficulty focusing or concentrating pain or inflammation in the mouth or on the tongue burning or pins and needles feeling in your hands or feet muscle cramps vision changes Learn more: Signs and symptoms of B12 deficiency

Additionally, about 10% to 15% of patients who have neurological symptoms and who start on chelation therapy develop a paradoxical worsening of their neurological disease

Dynamic plasma proteome suggests that cellular stress and immune dysregulation may contribute to PSE pathogenesis