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Given the role of NADPH in the process of phagocytic killing it should be clear that individuals with reduced ability to produce NADPH (such as those with G6PD deficiencies) may also manifest with symptoms that have similarities to those of classically inherited forms of CGD

10.1016/j.jagp.2013.03.014 Am

In autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis, chronic inflammation and oxidative stress can damage tissues and interfere with immune tolerance

Lindsey Bordone is a board-certified dermatologist and assistant professor of dermatology at Columbia University Medical Center

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