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Front Gen 9(247):1247:14

A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment

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This synergy allows the glutathione to work longer and more effectively

In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)