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Oral bioavailability, which is the measure of drug exposure in systemic circulation following oral dosing compared against IV dosing using AUC calculation, is critical to understanding if low systemic concentration comes from either poor absorption, first pass metabolism, or both ( in vivo stability

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Precisely weighed amounts of CKAAKN-NH-PEG 2000 -DSPE (1.36 mg), soybean lecithin (54.31 mg), cholesterol (9.27 mg), and oridonin (2 mg) were transferred into a round-bottom flask and dissolved in a chloroformmethanol mixture (1:1, v/v) to form a homogeneous solution

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J Asia Pac Entomol 23(4):890900