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(21) Here are just a few examples of the ways that certain chemicals can affect the thyroid: (22-35) PCBs can alter levels of T4 and TSH Pesticides may induce glucuronidation of thyroid hormones PFCs may interfere with thyroid hormone metabolism BFRs can bind to thyroid receptors and displace T4 from binding proteins BPAs can disrupt thyroid hormone action Air pollution particles can induce cell death and the self-destruction of tissue (such as thyroid tissue) observed in autoimmune diseases Exposure to certain VOCs can lead to an imbalance or deficiency in T3 Flame retardants can cause thyroid dysregulation When exposed to formaldehyde, rat thyroids shrink, T3 and T4 decrease, and TSH spikes PBDEs are endocrine-disrupting chemicals that interfere with thyroid hormone action PBDEs cause thyroid and liver tumors in rodents Exposure to air pollution in early pregnancy may interfere with a mothers thyroid function during pregnancy, affect thyroid hormone levels in the developing fetus, and potentially contribute to preterm birth Perhaps more alarming is that flame retardants can be found in furniture as well as many clothing items, even those marketed for children

This, and other characteristics of these devices, have made many wonder if e-cigarettes could serve as a gateway to the use of other nicotine/tobacco products