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Factors like dehydration, an empty stomach, or mixing nicotine with caffeine can significantly intensify these unpleasant side effects

Identifying Dehydration Symptoms in Smokers Dry mouth and throat are common signs of dehydration in smokers

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Nevertheless, complement activation in the pathogenesis of cardiovascular disease is well described, from the earliest signs of endothelial dysfunction, followed by progression to the formation of atherosclerotic plaques and vascular thrombus, with accompanied proinflammatory and procoagulant changes [63, 64]