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When compared with other modifiable risk factors for many diseases, tobacco consumption remains the leading preventable cause of morbidity and mortality globally 9-11

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For example, DiFranza and colleagues (2000) prospectively followed occasional adolescent smokers and observed that a large proportion experienced at least one symptom of nicotine dependence upon quitting, even in the first 4 weeks after initiating monthly smoking (at least two cigarettes within a 2-month period)