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Gene ontology (GO) analysis of upregulated DEGs in SCyte_lP cells demonstrated significant enrichment in respiratory chain complexes, especially complex IV, including key genes such as mt-Co1 , mt-Co2 , Cox5a , and Cox6c (Fig

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Fourth, heaviest smokers (in terms of early initiation or duration of smoking) may have died before the study began, potentially biasing our observed associations towards the null