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Transforming growth factor 1 (TGF-1) secreted by cancer-associated fibroblasts (CAFs) activates JUN signaling in hepatocellular carcinoma cells, leading to increased semaphorin-3C (SEMA3C) expression

For instance, changes in DNA methylation patterns, histone modifications, as well as circulating miRNA expression alterations may affect critical biological pathways, thereby influencing health outcomes in NS workers 220

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The sample size (n = 8 per group) was selected based on commonly reported group sizes in similar experimental hyperthyroidism studies and to ensure sufficient power for detecting biologically relevant differences in biochemical and histopathological parameters