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Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties

The specific monitoring protocol should be individualized based on patient risk factors, treatment indication, and duration of therapy

These improvements in cardiovascular risk markers, combined with enhanced insulin sensitivity and glucose metabolism, suggest tesofensine may provide comprehensive metabolic benefits for obese individuals with comorbid metabolic conditions

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors

, BurgosMorn E., PrezGuerrero C., and LpezLzaro M