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Smoking is the number one cause of preventable deaths in the United States, and nicotine replacement therapy (NRT) has given many smokers the ability to transition between cigarette smoking and being entirely nicotine-free (and smoking-free)

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We understand this because most hazardous substances in cigarette smoke are not present at detectable levels in the smoke-free alternatives or are found at significantly lower levels

Deep fungal infections involving the palate or maxilla are an important differential diagnosis for the clinical entity midline destructive disease. Other conditions that fall into this category include NKT-cell lymphoma, other infections such as tertiary syphilis, granulomatosis with polyangiitis (Wegener disease), cocaine use, and epithelial malignancy of surface or salivary gland origin.34 A biopsy readily distinguishes among these entities

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