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Abusers may inhale, by sniffing or snorting, chemical vapors directly from open containers or by huffing fumes from rags that are soaked in a chemical substance and then held to the face or stuffed in the mouth

For more on nicotine, including some of the most positive effects, see 10 Facts All Vapers Should Know About Nicotine

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On the other hand it might be a great opportunity for harm reduction and if you wait for the answers for the next five years millions of people might not have been helped