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In addition, although the design is pragmatic to include those with psychiatric or substance use comorbidities, trial burden (weekly visits, adherence to the protocol) might make retention problematic for these participants

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The description of e-cigarettes in wave 1 was as follows, E-cigarettes look like regular cigarettes, but are battery-powered and produce vapor instead of smoke. In wave 2, the definition of e-vapor products was broadened to electronic nicotine products, such as e-cigarettes, e-cigars, e-pipes, e-hookahs, personal vaporizers, vape pens, and hookah pens