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This limits the extent to which they can be considered a suitable control condition where experimental and control conditions are closely matched (e.g., due to familiarity)

Researchers found that alcohol and tobacco use combined cost more than a quarter of a billion disability-adjusted life-years worldwide, while illegal drugs only accounted for tens of millions in comparison

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it becomes a statement of masculinity, shaping how a man looks, smells, and ultimately feels

Journal of Substance Abuse Treatment