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Numerous studies have shown that the upregulation of NOXs in vascular tissues and cell types such as endothelial cells, smooth muscle cells, fibroblasts, and others plays a key role in atherogenesis by promoting endothelial dysfunction and vascular inflammation

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(Many of these reports have come via his stepmother, Shari Dahmer.) The atmosphere at home had become worse since the birth of Jeffreys younger brother, David, to whom so much demonstrative affection was offered that Jeffrey was left to draw the conclusion that he was somehow unworthy