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The unified ontology-based knowledge framework has been tested in the context of the EU Framework Program 7 TRANSFoRm project, where it was used to achieve data integration in a retrospective diabetes cohort study
The absence of a longitudinal follow-up limits the ability to track the progression of OSMF and other oral lesions over time, establish temporal relationships between risk factors (e.g., areca nut use) and lesion development and assess outcomes such as lesion regression or malignant transformation
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