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doi: 10.3390/ijms22073336 108 Gatzke-KoppLMRiisJLAhmadiHPiccerilloHLGrangerDABlairCBet al

Moderate alcohol consumption has been suggested to induce anti-inflammatory responses related to adenosine receptors, protein kinase C, nitric oxide synthase, and heat shock proteins, thereby resulting in cardioprotective effects 14,16

Mechanisms Nicotine is a well-established respiratory irritant 58 , but other chemicals in e-cigarettes (e.g., diacetyl 59 , propylene glycol, carbon monoxide, and formaldehyde 60 ) also have detrimental effects for lung function including respiratory volume 61

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