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demonstrate that long-term CS exposure in mice impairs the normal growth of lumbar vertebral bodies and deteriorates vertebral bone quality, and these results were attributed mainly to disorientation of newly total collagen fibers that were replaced during remodeling process after the CS-induced injury in bone tissue 89

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This classic approach has been commonly applied 35,36,37,38,39 and has key advantages 26 , including that it is relatively fast to apply and is more interpretable compared to more sophisticated methods, such as Bayesian regression models that perform shrinkage 39,40,41

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