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in this analysis, the IR was 0.66/100 patient-years (PY) in the ritlecitinib 50mg group.21 In a real-world study conducted in the United States, the IR for serious infections was 1.85/100 PY (95% CI, 1.652.08) in patients with AA.26 A dose-dependent increase in herpes zoster (HZ) infections was observed with ritlecitinib, which is consistent with former reports for other immunomodulators, including JAK inhibitors (JAKi).27,28 In the 50mg ritlecitinib group from the total-exposure cohort, the IR for HZ was 0.99/100 PY (95% CI, 0.601.55)

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doi: 10.1159/000336339 239

5-Amino-1MQ is a mechanistically distinct research compound