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It was famously used in the 1936 propaganda film Reefer Madness, which depicted cannabis in a highly sensationalized and negative light

At several p53 mutational hotspots common to all cancers, such as codons 248 and 273, a large fraction of the mutations are G to T events in lung cancers but are almost exclusively G to A transitions in non-tobacco-related cancers

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A five-year study of people with chronic bronchitis (COPD) who switched from smoking to vaping showed that they had fewer acute episodes, better lung function and could even walk further than a control group who continued to smoke