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[29] Mutations of p53 have been demonstrated in the cells from areas of some leukoplakias, especially those with dysplasia and in individuals who smoke and drink heavily

Snus use is associated with several cardiovascular risk factors, including lower education, male sex, alcohol intake, cigarette smoking, and physical inactivity [13]

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For example, this could provide insights on where physicians are having challenges, like prior authorization or questions around product side effects