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Availability of data and materials All data generated or analysed during this study are included in this published article [and its supplementary information files]

Despite early opposition from some leaderssuch as King James I of England, who condemned smoking as harmful and offensivetobacco use flourished

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Preclinical and clinical data suggests that although sociocultural influences significantly affect smoking adolescence, adolescent sensitivity to nicotine has strong neurobiological underpinnings ( Adolescence is a sensitive period for maturation of brain circuits that regulate cognition and emotion, with resulting vulnerability to the effects of nicotine and tobacco ( Adolescence is marked by major physical changes in the body, however the hallmark of this period is a major reorganization of forebrain circuitry ( Structural Changes in the Adolescent Brain The structural changes in the adolescent brain include prolonged reorganization of gray matter, white matter, and associated neurochemical systems