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To neutralize ROS, cells induce various antioxidant systems, including the activation of the protein machinery that produces glutathione [10], the most abundant antioxidant scavenger in all cells [11, 12]

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Int J Risk Saf Med

Figure 5 Because CB-839 alone had a limited effect on cell proliferation and apoptosis, we examined whether the metabolic changes associated with this drug would sensitize the CLL cell lines and primary cells to the targeted therapeutics

Oxidative stress and inflammatory cytokines can directly disrupt the BBB and damage neuronal tissue, which is likely to cause cognitive dysfunction and increase the risk of depression (116)