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S is a key protein in the pathology of Parkinsons disease (PD) [253], characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of S in the form of Lewy bodies and Lewy neurites

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Furthermore, dihydroethidine (DHE) staining showed that the proportion of DHE-positive cells after OGD treatment was higher than that in the control group, suggesting that the level of reactive oxygen species (ROS) was increased (Figure 3G)

A circular RNA generated from an intron of the insulin gene controls insulin secretion